I'm an analytical scientist with a PhD in Pharmaceutical Engineering and 5+ years of experience in bioanalytical method development, quantitative proteomics, and pharmacokinetic modeling. I build data science tools in Python and R for drug discovery and regulatory science.
- CMC analytical data science — stability modeling, method validation, DOE
- Mass spectrometry — LC-MS/MS pipelines, proteomics, oligonucleotide characterization
- PBPK / pharmacometrics — mechanistic PK modeling, special populations, dissolution
- Regulatory science — FDA/EMA submissions, bioequivalence, IVIVC, special populations
Languages
Data Science
Mass Spectrometry
LC-MS/MS Orbitrap Fusion Lumos Q Exactive HF-X SCIEX Triple Quad 6500+
Proteome Discoverer Skyline MassLynx XCalibur
Pharma / Regulatory
FDA BMV 2018 ICH Q1A/Q1E ICH M10 GMP/GLP
OSP PK-Sim v12 OSP MoBi v12 PBPK modeling GastroPlus
| Project | Field | Tools |
|---|---|---|
| CMC Stability Analyzer | ICH Q1E shelf-life prediction | Python · scipy · plotly |
| Method Validation Dashboard | Bioanalytical · FDA BMV 2018 | Python · scikit-learn · plotly |
| Proteomics LC-MS Pipeline | Quantitative proteomics · DIA | Python · seaborn · statsmodels |
| PK Simulator | NCA · compartmental PK | Python · scipy · plotly |
Complete implementation of the OSP PK-Sim v12 and MoBi v11/12 course exercises in Python and R.
| Project | Key concept | Tools |
|---|---|---|
| Full PBPK Model | Whole-body PBPK · IVIVE · Rodgers & Rowland | Python · R · deSolve |
| Oral PBPK Model | GI absorption · first-pass · oral PK | Python · R |
| Bayesian PBPK / MCMC | Parameter uncertainty · population Bayes | Python · R |
| Cancer Risk + Reverse Dosimetry | Reverse dosimetry · risk assessment | Python · R |
| Nanoparticle PBPK (QD705) | Nanoparticle distribution · MPS | Python · R |
| Project | Key concept | Tools |
|---|---|---|
| DDI Itraconazole + Midazolam | CYP3A4 competitive inhibition · AUC ratio | Python · R |
| Oral Administration & Populations | GI model · CYP3A5 polymorphism · ethnic variability | Python · R |
| Renal Impairment PBPK | CKD staging · GFR scaling · dose adjustment | Python · R |
| Hepatic Impairment PBPK | Child-Pugh · CYP3A4 · portal shunting | Python · R |
| Dapagliflozin Species Scaling | Rat → human translation · CYP2C8 | Python · R |
| Morphine Pediatric Scaling | Ontogeny · pediatric dose prediction | Python · R |
| Project | Key concept | Tools |
|---|---|---|
| Large Molecule PBPK & TMDD | ADC · FcRn · target-mediated drug disposition | Python · R |
| Adding an Organ: Tumor | EPR effect · cloned muscle · tumor distribution | Python · R |
| QSP: Tumor Growth Inhibition | Simeoni TGI · Gompertz · dynamic tumor volume | Python · R |
| Maternal-Fetal PBPK | Pregnancy physiology · fetal exposure · Dallmann 2018 | Python · R |
| Lysosomal Trapping PBPK | Henderson-Hasselbalch · intracellular pH partitioning | Python · R |
| Project | Key concept | Tools |
|---|---|---|
| MoBi Two-Container Model | Spatial compartments · neighborhoods · transport | Python · R |
| MoBi Observers | AUC · Kp · mass balance · reaction flux observers | Python · R |
| MoBi Formula Types | Explicit · Sum · Conditional · circadian clearance | Python · R |
| Project | Key concept | Tools |
|---|---|---|
| Particle Dissolution PBPK | Noyes-Whitney · PSD fitting · biorelevant media | Python · R |
| IVIVC — Metoprolol MR | Level A · Wagner-Nelson · FDA validation · Eddington 1998 | Python · R |
| Dermal Caffeine PBPK | Skin layers · hair follicle shunt · EPR | Python · R |
- Ahmed NT et al. Neutrophil elastase targets select proteins on human blood monocyte-derived macrophage cell surfaces. Int J Mol Sci. 2024;25(23):13038. DOI
- Islam MR, Ahmed NT et al. Decoding Oligonucleotide Stereochemistry. Analytical Chemistry (submitted)
- Ayubee MS, Ahmed NT et al. Synergistic antibacterial action of AgNP-ampicillin conjugates. PLoS One 2025. DOI
- PhD Pharmaceutical Engineering — Virginia Commonwealth University (2024)
- MS Pharmaceutical Nanotechnology — University of South Florida (2020)
- MPharm Pharmaceutical Chemistry — University of Dhaka (2019)
- OSP PK-Sim / MoBi Course (v12) — Completed all exercises
- FDA PBPK Modeling Workshop (2024, Dr. Raymond Yang)
- FDA Bioanalytical Method Validation Training
Pharmaceutical data scientist at the intersection of analytical chemistry, mass spectrometry, and regulatory PBPK modeling.