diff --git a/.github/workflows/bigendian.sh b/.github/workflows/bigendian.sh
new file mode 100644
index 0000000000..18d477f8b8
--- /dev/null
+++ b/.github/workflows/bigendian.sh
@@ -0,0 +1,34 @@
+#!/usr/bin/env bash
+
+set -e
+set -u
+set -x
+
+#
+# see: https://github.community/t/testing-against-multiple-architectures/17111/6
+#
+
+echo =================================
+lscpu | grep Endian
+echo =================================
+
+export DEBIAN_FRONTEND=${DEBIAN_FRONTEND:-noninteractive}
+
+apt-get update -y
+apt-get install -y \
+    git \
+    python3 \
+    python3-setuptools \
+    python3-setuptools-scm \
+    python3-pip \
+    python3-pytest \
+    python3-msgpack \
+    python3-fasteners \
+    python3-fsspec \
+    python3-numcodecs \
+    python3-asciitree
+
+python3 setup.py build  # Generate version
+python3 -m pip install -U fsspec
+python3 -m pip install --no-deps .
+python3 -m pytest -sv
diff --git a/.github/workflows/bigendian.yml b/.github/workflows/bigendian.yml
new file mode 100644
index 0000000000..77be63d16b
--- /dev/null
+++ b/.github/workflows/bigendian.yml
@@ -0,0 +1,26 @@
+# This workflow uses a docker image to simulate a big-endian
+# platform.
+name: Big-Endian Testing
+
+on:
+  push:
+    branches: [ main ]
+  pull_request:
+    branches: [ main ]
+
+jobs:
+  build:
+
+    runs-on: ubuntu-latest
+
+    steps:
+
+    - uses: actions/checkout@v2
+      with:
+        fetch-depth: 0
+
+    - run: docker run --rm --privileged multiarch/qemu-user-static:register --reset
+
+    - uses: docker://multiarch/ubuntu-core:s390x-focal
+      with:
+        args: 'bash .github/workflows/bigendian.sh'