diff --git a/internal/report/source.go b/internal/report/source.go
index 771f500ec1..8a8284f7ab 100644
--- a/internal/report/source.go
+++ b/internal/report/source.go
@@ -25,6 +25,7 @@ import (
 	"os"
 	"path/filepath"
 	"regexp"
+	"runtime"
 	"slices"
 	"sort"
 	"strconv"
@@ -1007,28 +1008,95 @@ func openSourceFile(path, searchPath, trim string) (*os.File, error) {
 	path = trimPath(path, trim, searchPath)
 	// If file is still absolute, require file to exist.
 	if filepath.IsAbs(path) {
-		f, err := os.Open(path)
-		return f, err
-	}
-	// Scan each component of the path.
-	for _, dir := range filepath.SplitList(searchPath) {
-		// Search up for every parent of each possible path.
-		for {
-			filename := filepath.Join(dir, path)
-			if f, err := os.Open(filename); err == nil {
-				return f, nil
-			}
-			parent := filepath.Dir(dir)
-			if parent == dir {
-				break
+		if f, err := tryOpenFile(path); err == nil {
+			return f, nil
+		}
+	} else {
+		// Scan each component of the path.
+		for _, dir := range filepath.SplitList(searchPath) {
+			// Search up for every parent of each possible path.
+			for {
+				filename := filepath.Join(dir, path)
+				if f, err := tryOpenFile(filename); err == nil {
+					return f, nil
+				}
+				parent := filepath.Dir(dir)
+				if parent == dir {
+					break
+				}
+				dir = parent
 			}
-			dir = parent
 		}
 	}
+	// Fall back to looking for Go standard library sources under the local
+	// $GOROOT/src, since profiles from Go programs refer to standard library
+	// files under the GOROOT of the machine where the program was built.
+	if f, err := openGorootSourceFile(path, gorootSrc); err == nil {
+		return f, nil
+	}
 
 	return nil, fmt.Errorf("could not find file %s on path %s", path, searchPath)
 }
 
+// tryOpenFile opens the file at filename if it exists and is not a directory,
+// which os.Open would also happily open.
+func tryOpenFile(filename string) (*os.File, error) {
+	f, err := os.Open(filename)
+	if err != nil {
+		return nil, err
+	}
+	stat, err := f.Stat()
+	if err != nil {
+		f.Close()
+		return nil, err
+	}
+	if stat.IsDir() {
+		f.Close()
+		return nil, fmt.Errorf("%s is a directory", filename)
+	}
+	return f, nil
+}
+
+// gorootSrc is the directory holding the Go standard library sources, if
+// known. runtime.GOROOT honors the $GOROOT environment variable and otherwise
+// reports the GOROOT this binary was built with, which is the Go installation
+// used to `go install` pprof in the common case.
+var gorootSrc = func() string {
+	if goroot := runtime.GOROOT(); goroot != "" {
+		return filepath.Join(goroot, "src")
+	}
+	return ""
+}()
+
+// openGorootSourceFile tries to open a Go standard library source file under
+// gorootSrc. Binaries built without -trimpath record standard library files
+// under the build machine's GOROOT (e.g. /usr/local/go/src/runtime/proc.go),
+// which may not exist locally, so resolve the path components after a "/src/"
+// component against gorootSrc. Binaries built with -trimpath record them
+// relative to $GOROOT/src (e.g. runtime/proc.go), so resolve relative paths
+// against gorootSrc directly.
+func openGorootSourceFile(path, gorootSrc string) (*os.File, error) {
+	if gorootSrc == "" {
+		return nil, fmt.Errorf("GOROOT is not known")
+	}
+	if !filepath.IsAbs(path) {
+		if f, err := tryOpenFile(filepath.Join(gorootSrc, path)); err == nil {
+			return f, nil
+		}
+	}
+	sPath := filepath.ToSlash(path)
+	for {
+		i := strings.Index(sPath, "/src/")
+		if i == -1 {
+			return nil, fmt.Errorf("could not find file %s under %s", path, gorootSrc)
+		}
+		sPath = sPath[i+len("/src/"):]
+		if f, err := tryOpenFile(filepath.Join(gorootSrc, filepath.FromSlash(sPath))); err == nil {
+			return f, nil
+		}
+	}
+}
+
 // trimPath cleans up a path by removing prefixes that are commonly
 // found on profiles plus configured prefixes.
 // TODO(aalexand): Consider optimizing out the redundant work done in this
diff --git a/internal/report/source_test.go b/internal/report/source_test.go
index dce64bc438..5ef39aabeb 100644
--- a/internal/report/source_test.go
+++ b/internal/report/source_test.go
@@ -180,6 +180,12 @@ func TestOpenSourceFile(t *testing.T) {
 			desc: "error when not found",
 			path: "foo.cc",
 		},
+		{
+			desc:       "directory is not matched",
+			searchPath: "$dir",
+			fs:         []string{"foo/bar.cc"},
+			path:       "foo",
+		},
 	} {
 		t.Run(tc.desc, func(t *testing.T) {
 			defer func() {
@@ -215,6 +221,131 @@ func TestOpenSourceFile(t *testing.T) {
 	}
 }
 
+func TestOpenGorootSourceFile(t *testing.T) {
+	gorootSrc := filepath.Join(t.TempDir(), "goroot", "src")
+	for _, f := range []string{"runtime/proc.go", "fmt/print.go"} {
+		path := filepath.Join(gorootSrc, filepath.FromSlash(f))
+		if err := os.MkdirAll(filepath.Dir(path), 0755); err != nil {
+			t.Fatalf("failed to create dir for %q: %v", path, err)
+		}
+		if err := os.WriteFile(path, nil, 0644); err != nil {
+			t.Fatalf("failed to create file %q: %v", path, err)
+		}
+	}
+	for _, tc := range []struct {
+		desc     string
+		path     string
+		noGoroot bool
+		wantPath string // Relative to gorootSrc. If empty, error is wanted.
+	}{
+		{
+			desc:     "absolute path under a foreign GOROOT",
+			path:     "/usr/local/go/src/runtime/proc.go",
+			wantPath: "runtime/proc.go",
+		},
+		{
+			desc:     "absolute path with multiple src components",
+			path:     "/home/user/src/go/src/fmt/print.go",
+			wantPath: "fmt/print.go",
+		},
+		{
+			desc:     "relative path from a -trimpath build",
+			path:     "runtime/proc.go",
+			wantPath: "runtime/proc.go",
+		},
+		{
+			desc: "absolute path without a src component",
+			path: "/usr/local/go/runtime/proc.go",
+		},
+		{
+			desc: "file missing from GOROOT",
+			path: "/usr/local/go/src/runtime/missing.go",
+		},
+		{
+			desc:     "unknown GOROOT",
+			path:     "/usr/local/go/src/runtime/proc.go",
+			noGoroot: true,
+		},
+	} {
+		t.Run(tc.desc, func(t *testing.T) {
+			src := gorootSrc
+			if tc.noGoroot {
+				src = ""
+			}
+			path := filepath.FromSlash(tc.path)
+			f, err := openGorootSourceFile(path, src)
+			if tc.wantPath == "" {
+				if err == nil {
+					gotPath := f.Name()
+					f.Close()
+					t.Fatalf("openGorootSourceFile(%q) = %q, want error", path, gotPath)
+				}
+				return
+			}
+			if err != nil {
+				t.Fatalf("openGorootSourceFile(%q) = err %v, want path %q", path, err, tc.wantPath)
+			}
+			defer f.Close()
+			if want := filepath.Join(src, filepath.FromSlash(tc.wantPath)); f.Name() != want {
+				t.Errorf("openGorootSourceFile(%q) = %q, want %q", path, f.Name(), want)
+			}
+		})
+	}
+}
+
+func TestOpenSourceFileGorootFallback(t *testing.T) {
+	fakeGorootSrc := filepath.Join(t.TempDir(), "goroot", "src")
+	path := filepath.Join(fakeGorootSrc, "runtime", "proc.go")
+	if err := os.MkdirAll(filepath.Dir(path), 0755); err != nil {
+		t.Fatalf("failed to create dir for %q: %v", path, err)
+	}
+	if err := os.WriteFile(path, nil, 0644); err != nil {
+		t.Fatalf("failed to create file %q: %v", path, err)
+	}
+	savedGorootSrc := gorootSrc
+	gorootSrc = fakeGorootSrc
+	defer func() { gorootSrc = savedGorootSrc }()
+
+	for _, tc := range []struct {
+		desc    string
+		path    string
+		wantErr bool
+	}{
+		{
+			desc: "absolute path under a foreign GOROOT",
+			path: "/usr/local/go/src/runtime/proc.go",
+		},
+		{
+			desc: "relative path from a -trimpath build",
+			path: "runtime/proc.go",
+		},
+		{
+			desc:    "not found under GOROOT falls through to error",
+			path:    "runtime/missing.go",
+			wantErr: true,
+		},
+	} {
+		t.Run(tc.desc, func(t *testing.T) {
+			f, err := openSourceFile(filepath.FromSlash(tc.path), "", "")
+			if tc.wantErr {
+				if err == nil {
+					gotPath := f.Name()
+					f.Close()
+					t.Fatalf("openSourceFile(%q) = %q, want error", tc.path, gotPath)
+				}
+				return
+			}
+			if err != nil {
+				t.Fatalf("openSourceFile(%q) = err %v, want path %q", tc.path, err, path)
+			}
+			defer f.Close()
+			if f.Name() != path {
+				t.Errorf("openSourceFile(%q) = %q, want %q", tc.path, f.Name(), path)
+			}
+		})
+	}
+}
+
 func TestIndentation(t *testing.T) {
 	for _, c := range []struct {
 		str        string