diff --git a/src/libraries/System.Private.CoreLib/src/System/String.Manipulation.cs b/src/libraries/System.Private.CoreLib/src/System/String.Manipulation.cs
index 558d0a399af12b..f6dc1a246469c0 100644
--- a/src/libraries/System.Private.CoreLib/src/System/String.Manipulation.cs
+++ b/src/libraries/System.Private.CoreLib/src/System/String.Manipulation.cs
@@ -6,8 +6,6 @@
 using System.Globalization;
 using System.Numerics;
 using System.Runtime.InteropServices;
-using System.Runtime.Intrinsics;
-using System.Runtime.Intrinsics.X86;
 using System.Text;
 using Internal.Runtime.CompilerServices;
 
@@ -1493,137 +1491,78 @@ private string[] SplitWithPostProcessing(ReadOnlySpan<int> sepList, ReadOnlySpan
         /// <param name="sepListBuilder"><see cref="ValueListBuilder{T}"/> to store indexes</param>
         private void MakeSeparatorList(ReadOnlySpan<char> separators, ref ValueListBuilder<int> sepListBuilder)
         {
-            // Special-case no separators to mean any whitespace is a separator.
-            if (separators.Length == 0)
+            char sep0, sep1, sep2;
+
+            switch (separators.Length)
             {
-                for (int i = 0; i < Length; i++)
-                {
-                    if (char.IsWhiteSpace(this[i]))
+                // Special-case no separators to mean any whitespace is a separator.
+                case 0:
+                    for (int i = 0; i < Length; i++)
                     {
-                        sepListBuilder.Append(i);
+                        if (char.IsWhiteSpace(this[i]))
+                        {
+                            sepListBuilder.Append(i);
+                        }
                     }
-                }
-            }
-
-            // Special-case the common cases of 1, 2, and 3 separators, with manual comparisons against each separator.
-            else if (separators.Length <= 3)
-            {
-                char sep0, sep1, sep2;
-                sep0 = separators[0];
-                sep1 = separators.Length > 1 ? separators[1] : sep0;
-                sep2 = separators.Length > 2 ? separators[2] : sep1;
-
-                if (Length >= 16 && Sse41.IsSupported)
-                {
-                    MakeSeparatorListVectorized(ref sepListBuilder, sep0, sep1, sep2);
-                    return;
-                }
+                    break;
 
-                for (int i = 0; i < Length; i++)
-                {
-                    char c = this[i];
-                    if (c == sep0 || c == sep1 || c == sep2)
+                // Special-case the common cases of 1, 2, and 3 separators, with manual comparisons against each separator.
+                case 1:
+                    sep0 = separators[0];
+                    for (int i = 0; i < Length; i++)
                     {
-                        sepListBuilder.Append(i);
+                        if (this[i] == sep0)
+                        {
+                            sepListBuilder.Append(i);
+                        }
                     }
-                }
-            }
-
-            // Handle > 3 separators with a probabilistic map, ala IndexOfAny.
-            // This optimizes for chars being unlikely to match a separator.
-            else
-            {
-                unsafe
-                {
-                    ProbabilisticMap map = default;
-                    uint* charMap = (uint*)&map;
-                    InitializeProbabilisticMap(charMap, separators);
-
+                    break;
+                case 2:
+                    sep0 = separators[0];
+                    sep1 = separators[1];
                     for (int i = 0; i < Length; i++)
                     {
                         char c = this[i];
-                        if (IsCharBitSet(charMap, (byte)c) && IsCharBitSet(charMap, (byte)(c >> 8)) &&
-                            separators.Contains(c))
+                        if (c == sep0 || c == sep1)
                         {
                             sepListBuilder.Append(i);
                         }
                     }
-                }
-            }
-        }
-
-        private void MakeSeparatorListVectorized(ref ValueListBuilder<int> sepListBuilder, char c, char c2, char c3)
-        {
-            // Redundant test so we won't prejit remainder of this method
-            // on platforms without SSE.
-            if (!Sse41.IsSupported)
-            {
-                throw new PlatformNotSupportedException();
-            }
-
-            // Constant that allows for the truncation of 16-bit (FFFF/0000) values within a register to 4-bit (F/0)
-            Vector128<byte> shuffleConstant = Vector128.Create(0x00, 0x02, 0x04, 0x06, 0x08, 0x0A, 0x0C, 0x0E, 0xFF, 0xFF, 0xFF, 0xFF, 0xFF, 0xFF, 0xFF, 0xFF);
-
-            Vector128<ushort> v1 = Vector128.Create(c);
-            Vector128<ushort> v2 = Vector128.Create(c2);
-            Vector128<ushort> v3 = Vector128.Create(c3);
-
-            ref char c0 = ref MemoryMarshal.GetReference(this.AsSpan());
-            int cond = Length & -Vector128<ushort>.Count;
-            int i = 0;
-
-            for (; i < cond; i += Vector128<ushort>.Count)
-            {
-                Vector128<ushort> charVector = ReadVector(ref c0, i);
-                Vector128<ushort> cmp = Sse2.CompareEqual(charVector, v1);
-
-                cmp = Sse2.Or(Sse2.CompareEqual(charVector, v2), cmp);
-                cmp = Sse2.Or(Sse2.CompareEqual(charVector, v3), cmp);
-
-                if (Sse41.TestZ(cmp, cmp)) { continue; }
-
-                Vector128<byte> mask = Sse2.ShiftRightLogical(cmp.AsUInt64(), 4).AsByte();
-                mask = Ssse3.Shuffle(mask, shuffleConstant);
-
-                uint lowBits = Sse2.ConvertToUInt32(mask.AsUInt32());
-                mask = Sse2.ShiftRightLogical(mask.AsUInt64(), 32).AsByte();
-                uint highBits = Sse2.ConvertToUInt32(mask.AsUInt32());
-
-                for (int idx = i; lowBits != 0; idx++)
-                {
-                    if ((lowBits & 0xF) != 0)
+                    break;
+                case 3:
+                    sep0 = separators[0];
+                    sep1 = separators[1];
+                    sep2 = separators[2];
+                    for (int i = 0; i < Length; i++)
                     {
-                        sepListBuilder.Append(idx);
+                        char c = this[i];
+                        if (c == sep0 || c == sep1 || c == sep2)
+                        {
+                            sepListBuilder.Append(i);
+                        }
                     }
+                    break;
 
-                    lowBits >>= 8;
-                }
-
-                for (int idx = i + 4; highBits != 0; idx++)
-                {
-                    if ((highBits & 0xF) != 0)
+                // Handle > 3 separators with a probabilistic map, ala IndexOfAny.
+                // This optimizes for chars being unlikely to match a separator.
+                default:
+                    unsafe
                     {
-                        sepListBuilder.Append(idx);
-                    }
-
-                    highBits >>= 8;
-                }
-            }
-
-            for (; i < Length; i++)
-            {
-                char curr = Unsafe.Add(ref c0, (IntPtr)(uint)i);
-                if (curr == c || curr == c2 || curr == c3)
-                {
-                    sepListBuilder.Append(i);
-                }
-            }
+                        ProbabilisticMap map = default;
+                        uint* charMap = (uint*)&map;
+                        InitializeProbabilisticMap(charMap, separators);
 
-            static Vector128<ushort> ReadVector(ref char c0, int offset)
-            {
-                ref char ci = ref Unsafe.Add(ref c0, (IntPtr)(uint)offset);
-                ref byte b = ref Unsafe.As<char, byte>(ref ci);
-                return Unsafe.ReadUnaligned<Vector128<ushort>>(ref b);
+                        for (int i = 0; i < Length; i++)
+                        {
+                            char c = this[i];
+                            if (IsCharBitSet(charMap, (byte)c) && IsCharBitSet(charMap, (byte)(c >> 8)) &&
+                                separators.Contains(c))
+                            {
+                                sepListBuilder.Append(i);
+                            }
+                        }
+                    }
+                    break;
             }
         }
 
