diff --git a/docs/workflow/testing/libraries/testing-android.md b/docs/workflow/testing/libraries/testing-android.md
index 4c753f6832ce56..596d7851f1a8ed 100644
--- a/docs/workflow/testing/libraries/testing-android.md
+++ b/docs/workflow/testing/libraries/testing-android.md
@@ -46,15 +46,6 @@ mkdir ${ANDROID_SDK_ROOT} && unzip ~/asdk.zip -d ${ANDROID_SDK_ROOT}/cmdline-too
 yes | ${ANDROID_SDK_ROOT}/cmdline-tools/tools/bin/sdkmanager --sdk_root=${ANDROID_SDK_ROOT} --licenses
 ${ANDROID_SDK_ROOT}/cmdline-tools/tools/bin/sdkmanager --sdk_root=${ANDROID_SDK_ROOT} "platform-tools" "platforms;android-${SDK_API_LEVEL}" "build-tools;${SDK_BUILD_TOOLS}"
 
-# We also need to download precompiled binaries and headers for OpenSSL from maven, this step is a temporary hack
-# and will be removed once we figure out how to integrate OpenSSL properly as a dependency
-export ANDROID_OPENSSL_AAR=~/openssl-android
-curl https://maven.google.com/com/android/ndk/thirdparty/openssl/${OPENSSL_VER}/openssl-${OPENSSL_VER}.aar -L --output ~/openssl.zip
-unzip ~/openssl.zip -d ${ANDROID_OPENSSL_AAR} && rm -rf ~/openssl.zip
-printf "\n\nexport ANDROID_NDK_ROOT=${ANDROID_NDK_ROOT}\nexport ANDROID_SDK_ROOT=${ANDROID_SDK_ROOT}\nexport ANDROID_OPENSSL_AAR=${ANDROID_OPENSSL_AAR}\n" >> ${BASHRC}
-```
-Save it to a file (e.g. `deps.sh`) and execute using `source` (e.g. `chmod +x deps.sh && source ./deps.sh`) in order to propogate the `ANDROID_NDK_ROOT`, `ANDROID_SDK_ROOT` and `ANDROID_OPENSSL_AAR` environment variables to the current process.
-
 ## Building Libs and Tests for Android
 
 Now we're ready to build everything for Android:
diff --git a/eng/install-native-dependencies.sh b/eng/install-native-dependencies.sh
index 1fdc2d3ba3a21d..b32774a68a7f07 100755
--- a/eng/install-native-dependencies.sh
+++ b/eng/install-native-dependencies.sh
@@ -46,19 +46,8 @@ elif [ "$1" = "OSX" ] || [ "$1" = "tvOS" ] || [ "$1" = "iOS" ]; then
     if [ "$?" != "0" ]; then
         exit 1;
     fi
-elif [ "$1" = "Android" ]; then
-    if [ -z "${ANDROID_OPENSSL_AAR}" ]; then
-        echo "The ANDROID_OPENSSL_AAR variable is not set. OpenSSL will not be installed."
-        exit 0;
-    fi
-    if [ -d "${ANDROID_OPENSSL_AAR}" ]; then
-        exit 0;
-    fi
-    OPENSSL_VER=1.1.1g-alpha-1
-    curl https://maven.google.com/com/android/ndk/thirdparty/openssl/${OPENSSL_VER}/openssl-${OPENSSL_VER}.aar -L --output /tmp/openssl.zip
-    unzip /tmp/openssl.zip -d "${ANDROID_OPENSSL_AAR}" && rm -rf /tmp/openssl.zip
 else
-    echo "Must pass \"Linux\", \"Android\", \"tvOS\", \"iOS\" or \"OSX\" as first argument."
+    echo "Must pass \"Linux\", \"tvOS\", \"iOS\" or \"OSX\" as first argument."
     exit 1
 fi
 
diff --git a/eng/pipelines/common/global-build-job.yml b/eng/pipelines/common/global-build-job.yml
index 3c4754e6ba273c..126cecfacaf05b 100644
--- a/eng/pipelines/common/global-build-job.yml
+++ b/eng/pipelines/common/global-build-job.yml
@@ -86,10 +86,6 @@ jobs:
         ${{ if ne(parameters.enableRichCodeNavigation, true) }}:
           value: ''
 
-      - ${{ if eq(parameters.osGroup, 'Android') }}:
-        - name: ANDROID_OPENSSL_AAR
-          value: /tmp/openssl-android
-
       - ${{ each variable in parameters.variables }}:
         - ${{ variable }}
 
@@ -108,7 +104,7 @@ jobs:
           artifact: Mono_Offsets_${{monoCrossAOTTargetOS}}
           path: '$(Build.SourcesDirectory)/artifacts/obj/mono/offsetfiles'
 
-    - ${{ if in(parameters.osGroup, 'OSX', 'iOS', 'tvOS', 'Android') }}:
+    - ${{ if in(parameters.osGroup, 'OSX', 'iOS', 'tvOS') }}:
       - script: $(Build.SourcesDirectory)/eng/install-native-dependencies.sh ${{ parameters.osGroup }} ${{ parameters.archType }} azDO
         displayName: Install Build Dependencies
 
diff --git a/eng/pipelines/runtime-staging.yml b/eng/pipelines/runtime-staging.yml
index 97a34f7f33d029..01ee98adb01def 100644
--- a/eng/pipelines/runtime-staging.yml
+++ b/eng/pipelines/runtime-staging.yml
@@ -64,6 +64,7 @@ jobs:
     buildConfig: Release
     runtimeFlavor: mono
     platforms:
+    - Android_x86
     - Android_x64
     - iOSSimulator_x64
     variables:
@@ -133,6 +134,17 @@ jobs:
             eq(variables['monoContainsChange'], true),
             eq(variables['isFullMatrix'], true))
 
+- template: /eng/pipelines/common/platform-matrix.yml
+  parameters:
+    jobTemplate: /eng/pipelines/common/global-build-job.yml
+    buildConfig: Release
+    platforms:
+    - Android_arm
+    jobParameters:
+      testGroup: innerloop
+      nameSuffix: Build_Subset_Mono
+      buildArgs: -subset mono+libs
+
 #
 # Build the whole product using Mono and run libraries tests
 #
@@ -252,34 +264,6 @@ jobs:
         creator: dotnet-bot
         testRunNamePrefixSuffix: Mono_$(_BuildConfig)
 
-#
-# Build Mono and Libraries for Android using Android native crypto instead of OpenSSL
-#
-- template: /eng/pipelines/common/platform-matrix.yml
-  parameters:
-    jobTemplate: /eng/pipelines/common/global-build-job.yml
-    buildConfig: Release
-    runtimeFlavor: mono
-    platforms:
-    - Android_x64
-    - Android_x86
-    - Android_arm64
-    variables:
-      # disable using OpenSSL
-      - name: ANDROID_OPENSSL_AAR
-        value: ''
-      # map dependencies variables to local variables
-      - name: librariesContainsChange
-        value: $[ dependencies.evaluate_paths.outputs['SetPathVars_libraries.containsChange'] ]
-    jobParameters:
-      nameSuffix: Libraries_Mono_AndroidCrypto
-      buildArgs: -s mono+libs -c $(_BuildConfig)
-      timeoutInMinutes: 180
-      condition: >-
-        or(
-          eq(dependencies.evaluate_paths.outputs['SetPathVars_libraries.containsChange'], true),
-          eq(variables['isFullMatrix'], true))
-
 # Run disabled installer tests on Linux x64
 - template: /eng/pipelines/common/platform-matrix.yml
   parameters:
diff --git a/eng/pipelines/runtime.yml b/eng/pipelines/runtime.yml
index e0d5603cba234c..4819accff31f08 100644
--- a/eng/pipelines/runtime.yml
+++ b/eng/pipelines/runtime.yml
@@ -222,7 +222,6 @@ jobs:
     buildConfig: ${{ variables.debugOnPrReleaseOnRolling }}
     runtimeFlavor: mono
     platforms:
-    - Android_x86
     - MacCatalyst_x64
     - MacCatalyst_arm64
     - tvOSSimulator_x64
@@ -246,7 +245,6 @@ jobs:
     buildConfig: Release
     runtimeFlavor: mono
     platforms:
-    - Android_arm
     - tvOS_arm64
     - iOS_arm
     - Linux_musl_x64
diff --git a/eng/testing/AndroidRunnerTemplate.sh b/eng/testing/AndroidRunnerTemplate.sh
index 0fd3a4a77c55a7..26698577798c1d 100644
--- a/eng/testing/AndroidRunnerTemplate.sh
+++ b/eng/testing/AndroidRunnerTemplate.sh
@@ -40,6 +40,7 @@ $HARNESS_RUNNER android test                \
     --package-name="net.dot.$ASSEMBLY_NAME" \
     --app="$EXECUTION_DIR/bin/$TEST_NAME.apk" \
     --output-directory="$XHARNESS_OUT" \
+    --timeout=1800 \
     $EXPECTED_EXIT_CODE
 
 _exitCode=$?
diff --git a/eng/testing/tests.mobile.targets b/eng/testing/tests.mobile.targets
index dad68387f86b5a..d287996e15eeb6 100644
--- a/eng/testing/tests.mobile.targets
+++ b/eng/testing/tests.mobile.targets
@@ -68,13 +68,6 @@
       </AotInputAssemblies>
     </ItemGroup>
 
-    <Copy Condition="'$(ANDROID_OPENSSL_AAR)' != ''"
-          SourceFiles="$(ANDROID_OPENSSL_AAR)\prefab\modules\crypto\libs\android.$(AndroidAbi)\libcrypto.so"
-          DestinationFolder="$(PublishDir)" SkipUnchangedFiles="true"/>
-    <Copy Condition="'$(ANDROID_OPENSSL_AAR)' != ''"
-          SourceFiles="$(ANDROID_OPENSSL_AAR)\prefab\modules\ssl\libs\android.$(AndroidAbi)\libssl.so"
-          DestinationFolder="$(PublishDir)" SkipUnchangedFiles="true"/>
-
     <WriteLinesToFile File="$(PublishDir)xunit-excludes.txt" Lines="$(XunitExcludesTxtFileContent)" />
     
     <MakeDir Directories="$(_MobileIntermediateOutputPath)" 
diff --git a/src/libraries/Common/tests/TestUtilities/System/PlatformDetection.cs b/src/libraries/Common/tests/TestUtilities/System/PlatformDetection.cs
index 32801918ebfe21..b163e97186178f 100644
--- a/src/libraries/Common/tests/TestUtilities/System/PlatformDetection.cs
+++ b/src/libraries/Common/tests/TestUtilities/System/PlatformDetection.cs
@@ -26,7 +26,7 @@ public static partial class PlatformDetection
         public static bool IsMonoInterpreter => GetIsRunningOnMonoInterpreter();
         public static bool IsFreeBSD => RuntimeInformation.IsOSPlatform(OSPlatform.Create("FREEBSD"));
         public static bool IsNetBSD => RuntimeInformation.IsOSPlatform(OSPlatform.Create("NETBSD"));
-        public static bool IsAndroid => RuntimeInformation.IsOSPlatform(OSPlatform.Create("Android"));
+        public static bool IsAndroid => RuntimeInformation.IsOSPlatform(OSPlatform.Create("ANDROID"));
         public static bool IsiOS => RuntimeInformation.IsOSPlatform(OSPlatform.Create("IOS"));
         public static bool IstvOS => RuntimeInformation.IsOSPlatform(OSPlatform.Create("TVOS"));
         public static bool IsMacCatalyst => RuntimeInformation.IsOSPlatform(OSPlatform.Create("MACCATALYST"));
diff --git a/src/libraries/Native/Unix/CMakeLists.txt b/src/libraries/Native/Unix/CMakeLists.txt
index fab7c06dfc3d1a..f47135fd8871c8 100644
--- a/src/libraries/Native/Unix/CMakeLists.txt
+++ b/src/libraries/Native/Unix/CMakeLists.txt
@@ -254,13 +254,8 @@ elseif(CLR_CMAKE_TARGET_TVOS)
     #add_subdirectory(System.Net.Security.Native) # no gssapi on tvOS, see https://developer.apple.com/documentation/gss
     # System.Security.Cryptography.Native is intentionally disabled on tvOS
     # it is only used for interacting with OpenSSL which isn't useful there
-elseif(CLR_CMAKE_TARGET_ANDROID AND NOT CROSS_ROOTFS)
-    #add_subdirectory(System.Net.Security.Native) # TODO: reenable
-    if (NOT "$ENV{ANDROID_OPENSSL_AAR}" STREQUAL "")
-        message("Using Android OpenSSL")
-        set(PREFER_OPENSSL_ANDROID 1)
-        add_subdirectory(System.Security.Cryptography.Native)
-    endif()
+elseif(CLR_CMAKE_TARGET_ANDROID)
+    add_subdirectory(System.Security.Cryptography.Native.Android)
 else()
     add_subdirectory(System.Globalization.Native)
     add_subdirectory(System.Net.Security.Native)
@@ -270,9 +265,3 @@ endif()
 if(CLR_CMAKE_TARGET_OSX OR CLR_CMAKE_TARGET_MACCATALYST OR CLR_CMAKE_TARGET_IOS OR CLR_CMAKE_TARGET_TVOS)
     add_subdirectory(System.Security.Cryptography.Native.Apple)
 endif()
-
-# if ANDROID_OPENSSL_AAR is not set - use Android Native Crypto (it's going to replace openssl eventually)
-if(CLR_CMAKE_TARGET_ANDROID AND NOT PREFER_OPENSSL_ANDROID)
-    message("Using Android Native Crypto")
-    add_subdirectory(System.Security.Cryptography.Native.Android)
-endif()
diff --git a/src/libraries/Native/Unix/System.Security.Cryptography.Native/extra_libs.cmake b/src/libraries/Native/Unix/System.Security.Cryptography.Native/extra_libs.cmake
index 5a0776577a98ac..3090da4e9d4121 100644
--- a/src/libraries/Native/Unix/System.Security.Cryptography.Native/extra_libs.cmake
+++ b/src/libraries/Native/Unix/System.Security.Cryptography.Native/extra_libs.cmake
@@ -3,28 +3,9 @@ macro(append_extra_cryptography_libs NativeLibsExtra)
     if(CMAKE_STATIC_LIB_LINK)
        set(CMAKE_FIND_LIBRARY_SUFFIXES .a)
     endif(CMAKE_STATIC_LIB_LINK)
-    
-    if(CLR_CMAKE_TARGET_ANDROID AND NOT CROSS_ROOTFS)
-        # TEMP: consume OpenSSL dependencies from external sources via env. variables
-        set(OPENSSL_FOUND 1)
-        set(OPENSSL_INCLUDE_DIR $ENV{ANDROID_OPENSSL_AAR}/prefab/modules/ssl/include)
-        if(CLR_CMAKE_TARGET_ARCH_ARM64)
-            set(OPENSSL_CRYPTO_LIBRARY $ENV{ANDROID_OPENSSL_AAR}/prefab/modules/crypto/libs/android.arm64-v8a/libcrypto.so)
-            set(OPENSSL_SSL_LIBRARY $ENV{ANDROID_OPENSSL_AAR}/prefab/modules/ssl/libs/android.arm64-v8a/libssl.so)
-        elseif(CLR_CMAKE_TARGET_ARCH_ARM)
-            set(OPENSSL_CRYPTO_LIBRARY $ENV{ANDROID_OPENSSL_AAR}/prefab/modules/crypto/libs/android.armeabi-v7a/libcrypto.so)
-            set(OPENSSL_SSL_LIBRARY $ENV{ANDROID_OPENSSL_AAR}/prefab/modules/ssl/libs/android.armeabi-v7a/libssl.so)
-        elseif(CLR_CMAKE_TARGET_ARCH_I386)
-            set(OPENSSL_CRYPTO_LIBRARY $ENV{ANDROID_OPENSSL_AAR}/prefab/modules/crypto/libs/android.x86/libcrypto.so)
-            set(OPENSSL_SSL_LIBRARY $ENV{ANDROID_OPENSSL_AAR}/prefab/modules/ssl/libs/android.x86/libssl.so)
-        else()
-            set(OPENSSL_CRYPTO_LIBRARY $ENV{ANDROID_OPENSSL_AAR}/prefab/modules/crypto/libs/android.x86_64/libcrypto.so)
-            set(OPENSSL_SSL_LIBRARY $ENV{ANDROID_OPENSSL_AAR}/prefab/modules/ssl/libs/android.x86_64/libssl.so)
-        endif()
-    else()
-        find_package(OpenSSL)
-    endif()
-    
+
+    find_package(OpenSSL)
+
     if(NOT OPENSSL_FOUND)
         message(FATAL_ERROR "!!! Cannot find libssl and System.Security.Cryptography.Native cannot build without it. Try installing libssl-dev (on Linux, but this may vary by distro) or openssl (on macOS) !!!. See the requirements document for your specific operating system: https://github.com/dotnet/runtime/tree/main/docs/workflow/requirements.")
     endif(NOT OPENSSL_FOUND)
diff --git a/src/libraries/System.Collections.Immutable/tests/ImmutableArrayTest.cs b/src/libraries/System.Collections.Immutable/tests/ImmutableArrayTest.cs
index 7349cefa67b5c3..14a42fba179564 100644
--- a/src/libraries/System.Collections.Immutable/tests/ImmutableArrayTest.cs
+++ b/src/libraries/System.Collections.Immutable/tests/ImmutableArrayTest.cs
@@ -1984,6 +1984,7 @@ public void IStructuralEquatableEqualsNullComparerInvalid()
 
         [Theory]
         [MemberData(nameof(IStructuralEquatableGetHashCodeData))]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/37069", TestPlatforms.Android)]
         public void IStructuralEquatableGetHashCode(IEnumerable<int> source, IEqualityComparer comparer)
         {
             var array = source.ToImmutableArray();
diff --git a/src/libraries/System.Collections.NonGeneric/tests/CaseInsensitiveComparerTests.cs b/src/libraries/System.Collections.NonGeneric/tests/CaseInsensitiveComparerTests.cs
index 6a0428686cb38a..14261e4c8c031c 100644
--- a/src/libraries/System.Collections.NonGeneric/tests/CaseInsensitiveComparerTests.cs
+++ b/src/libraries/System.Collections.NonGeneric/tests/CaseInsensitiveComparerTests.cs
@@ -65,6 +65,7 @@ public void Ctor_CultureInfo_Compare(object a, object b, int expected)
         }
 
         [Fact]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/37069", TestPlatforms.Android)]
         public void Ctor_CultureInfo_Compare_TurkishI()
         {
             var cultureNames = Helpers.TestCultureNames;
diff --git a/src/libraries/System.Collections.NonGeneric/tests/CaseInsensitiveHashCodeProviderTests.cs b/src/libraries/System.Collections.NonGeneric/tests/CaseInsensitiveHashCodeProviderTests.cs
index f41a9225e02468..e9120f915aaf3d 100644
--- a/src/libraries/System.Collections.NonGeneric/tests/CaseInsensitiveHashCodeProviderTests.cs
+++ b/src/libraries/System.Collections.NonGeneric/tests/CaseInsensitiveHashCodeProviderTests.cs
@@ -95,6 +95,7 @@ public void Ctor_CultureInfo_ChangeCurrentCulture_GetHashCodeCompare(object a, o
         }
 
         [Fact]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/37069", TestPlatforms.Android)]
         public void Ctor_CultureInfo_GetHashCodeCompare_TurkishI()
         {
             var cultureNames = Helpers.TestCultureNames;
@@ -150,6 +151,7 @@ public void Default_GetHashCodeCompare(object a, object b, bool expected)
         }
 
         [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsNotInvariantGlobalization))]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/37069", TestPlatforms.Android)]
         public void Default_Compare_TurkishI()
         {
             // Turkish has lower-case and upper-case version of the dotted "i", so the upper case of "i" (U+0069) isn't "I" (U+0049)
diff --git a/src/libraries/System.IO.Compression/tests/CompressionStreamUnitTests.Deflate.cs b/src/libraries/System.IO.Compression/tests/CompressionStreamUnitTests.Deflate.cs
index 2cdf0224710dd8..4feaee51111be1 100644
--- a/src/libraries/System.IO.Compression/tests/CompressionStreamUnitTests.Deflate.cs
+++ b/src/libraries/System.IO.Compression/tests/CompressionStreamUnitTests.Deflate.cs
@@ -30,6 +30,7 @@ public static IEnumerable<object[]> DecompressFailsWithWrapperStream_MemberData(
         /// <summary>Test to pass GZipStream data and ZLibStream data to a DeflateStream</summary>
         [Theory]
         [MemberData(nameof(DecompressFailsWithWrapperStream_MemberData))]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/36845", TestPlatforms.Android)]
         public async Task DecompressFailsWithWrapperStream(string uncompressedPath, string newDirectory, string newSuffix)
         {
             string fileName = Path.Combine(newDirectory, Path.GetFileName(uncompressedPath) + newSuffix);
diff --git a/src/libraries/System.IO.Pipes/tests/NamedPipeTests/NamedPipeTest.UnixDomainSockets.cs b/src/libraries/System.IO.Pipes/tests/NamedPipeTests/NamedPipeTest.UnixDomainSockets.cs
index 3f5a9e352d3484..7bab6b302d4dec 100644
--- a/src/libraries/System.IO.Pipes/tests/NamedPipeTests/NamedPipeTest.UnixDomainSockets.cs
+++ b/src/libraries/System.IO.Pipes/tests/NamedPipeTests/NamedPipeTest.UnixDomainSockets.cs
@@ -11,6 +11,7 @@ public class NamedPipeTest_UnixDomainSockets
     {
         [Fact]
         [PlatformSpecific(TestPlatforms.AnyUnix)]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49873", TestPlatforms.Android)]
         public void NamedPipeServer_Connects_With_UnixDomainSocketEndPointClient()
         {
             string pipeName = Path.Combine("/tmp", "pipe-tests-corefx-" + Path.GetRandomFileName());
@@ -28,6 +29,7 @@ public void NamedPipeServer_Connects_With_UnixDomainSocketEndPointClient()
 
         [Fact]
         [PlatformSpecific(TestPlatforms.AnyUnix)]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49873", TestPlatforms.Android)]
         public async Task NamedPipeClient_Connects_With_UnixDomainSocketEndPointServer()
         {
             string pipeName = Path.Combine("/tmp", "pipe-tests-corefx-" + Path.GetRandomFileName());
diff --git a/src/libraries/System.Net.Security/src/System.Net.Security.csproj b/src/libraries/System.Net.Security/src/System.Net.Security.csproj
index c60878d25835e1..6c0a5b530fdf59 100644
--- a/src/libraries/System.Net.Security/src/System.Net.Security.csproj
+++ b/src/libraries/System.Net.Security/src/System.Net.Security.csproj
@@ -10,9 +10,7 @@
     <GeneratePlatformNotSupportedAssemblyMessage Condition="'$(TargetsAnyOS)' == 'true'">SR.SystemNetSecurity_PlatformNotSupported</GeneratePlatformNotSupportedAssemblyMessage>
   </PropertyGroup>
   <PropertyGroup>
-    <!-- Use Android native crypto when ANDROID_OPENSSL_AAR is not defined.
-         TODO: [AndroidCrypto] Remove ANDROID_OPENSSL_AAR check once Android native crypto is complete -->
-    <UseAndroidCrypto Condition="'$(TargetsAndroid)' == 'true' and '$(ANDROID_OPENSSL_AAR)' == ''">true</UseAndroidCrypto>
+    <UseAndroidCrypto Condition="'$(TargetsAndroid)' == 'true'">true</UseAndroidCrypto>
     <UseAppleCrypto Condition="'$(TargetsOSX)' == 'true' or '$(TargetsiOS)' == 'true' or '$(TargetstvOS)' == 'true'">true</UseAppleCrypto>
   </PropertyGroup>
   <PropertyGroup Condition="'$(UseAndroidCrypto)' == 'true' or '$(UseAppleCrypto)' == 'true'">
diff --git a/src/libraries/System.Private.Uri/tests/FunctionalTests/UriTests.cs b/src/libraries/System.Private.Uri/tests/FunctionalTests/UriTests.cs
index 2b2222f315d823..24be0ef8227434 100644
--- a/src/libraries/System.Private.Uri/tests/FunctionalTests/UriTests.cs
+++ b/src/libraries/System.Private.Uri/tests/FunctionalTests/UriTests.cs
@@ -750,6 +750,7 @@ public static void Uri_CachesDnsSafeHost()
         }
 
         [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsThreadingSupported))]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49932", TestPlatforms.Android)]
         public static void Uri_DoesNotLockOnString()
         {
             // Don't intern the string we lock on
diff --git a/src/libraries/System.Runtime.Extensions/tests/System/AppDomainTests.cs b/src/libraries/System.Runtime.Extensions/tests/System/AppDomainTests.cs
index baaeec5847b49f..1101f747efccdd 100644
--- a/src/libraries/System.Runtime.Extensions/tests/System/AppDomainTests.cs
+++ b/src/libraries/System.Runtime.Extensions/tests/System/AppDomainTests.cs
@@ -46,6 +46,7 @@ public void RelativeSearchPath_Is_Null()
         [Fact]
         [PlatformSpecific(~TestPlatforms.Browser)] // throws pNSE
         [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49868", TestPlatforms.Android)]
         public void TargetFrameworkTest()
         {
             const int ExpectedExitCode = 0;
@@ -794,7 +795,7 @@ public static void GetPermissionSet()
         }
 
         [Theory]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/34030", TestPlatforms.Linux | TestPlatforms.Browser, TargetFrameworkMonikers.Netcoreapp, TestRuntimes.Mono)]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/34030", TestPlatforms.Linux | TestPlatforms.Browser | TestPlatforms.Android, TargetFrameworkMonikers.Netcoreapp, TestRuntimes.Mono)]
         [MemberData(nameof(TestingCreateInstanceFromObjectHandleData))]
         public static void TestingCreateInstanceFromObjectHandle(string physicalFileName, string assemblyFile, string type, string returnedFullNameType, Type exceptionType)
         {
@@ -894,7 +895,7 @@ public static void TestingCreateInstanceObjectHandle(string assemblyName, string
         };
 
         [Theory]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/34030", TestPlatforms.Linux | TestPlatforms.Browser, TargetFrameworkMonikers.Netcoreapp, TestRuntimes.Mono)]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/34030", TestPlatforms.Linux | TestPlatforms.Browser | TestPlatforms.Android, TargetFrameworkMonikers.Netcoreapp, TestRuntimes.Mono)]
         [MemberData(nameof(TestingCreateInstanceFromObjectHandleFullSignatureData))]
         public static void TestingCreateInstanceFromObjectHandleFullSignature(string physicalFileName, string assemblyFile, string type, bool ignoreCase, BindingFlags bindingAttr, Binder binder, object[] args, CultureInfo culture, object[] activationAttributes, string returnedFullNameType)
         {
diff --git a/src/libraries/System.Runtime.Extensions/tests/System/Environment.Exit.cs b/src/libraries/System.Runtime.Extensions/tests/System/Environment.Exit.cs
index d627a3099f34a8..2b49f421fb3418 100644
--- a/src/libraries/System.Runtime.Extensions/tests/System/Environment.Exit.cs
+++ b/src/libraries/System.Runtime.Extensions/tests/System/Environment.Exit.cs
@@ -44,6 +44,7 @@ public static void ExitCode_Roundtrips(int exitCode)
         [InlineData(3)] // using Exit(exitCode)
         [PlatformSpecific(~TestPlatforms.Browser)] // throws PNSE
         [ActiveIssue("https://github.com/dotnet/runtime/issues/49568", typeof(PlatformDetection), nameof(PlatformDetection.IsMacOsAppleSilicon))]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49868", TestPlatforms.Android)]
         public static void ExitCode_VoidMainAppReturnsSetValue(int mode)
         {
             int expectedExitCode = 123;
diff --git a/src/libraries/System.Runtime.Extensions/tests/System/EnvironmentTests.cs b/src/libraries/System.Runtime.Extensions/tests/System/EnvironmentTests.cs
index fd6791c09817d2..8415493fbf0e17 100644
--- a/src/libraries/System.Runtime.Extensions/tests/System/EnvironmentTests.cs
+++ b/src/libraries/System.Runtime.Extensions/tests/System/EnvironmentTests.cs
@@ -399,6 +399,7 @@ public void GetSystemDirectory()
         [InlineData(Environment.SpecialFolder.MyMusic, Environment.SpecialFolderOption.DoNotVerify)]
         [InlineData(Environment.SpecialFolder.MyPictures, Environment.SpecialFolderOption.DoNotVerify)]
         [InlineData(Environment.SpecialFolder.Fonts, Environment.SpecialFolderOption.DoNotVerify)]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49868", TestPlatforms.Android)]
         public void GetFolderPath_Unix_NonEmptyFolderPaths(Environment.SpecialFolder folder, Environment.SpecialFolderOption option)
         {
             Assert.NotEmpty(Environment.GetFolderPath(folder, option));
diff --git a/src/libraries/System.Runtime.Extensions/tests/System/OperatingSystemTests.cs b/src/libraries/System.Runtime.Extensions/tests/System/OperatingSystemTests.cs
index c0e05a97e37d03..ffbcfbccd2966a 100644
--- a/src/libraries/System.Runtime.Extensions/tests/System/OperatingSystemTests.cs
+++ b/src/libraries/System.Runtime.Extensions/tests/System/OperatingSystemTests.cs
@@ -93,6 +93,7 @@ public static void IsOSPlatformVersionAtLeast_InvalidArgs_Throws()
         public static void TestIsOSVersionAtLeast_FreeBSD() => TestIsOSVersionAtLeast("FreeBSD");
 
         [Fact, PlatformSpecific(TestPlatforms.Android)]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49868", TestPlatforms.Android)]
         public static void TestIsOSPlatform_Android() => TestIsOSPlatform("Android", OperatingSystem.IsAndroid);
 
         [Fact, PlatformSpecific(TestPlatforms.Android)]
diff --git a/src/libraries/System.Runtime.Extensions/tests/System/StringComparer.cs b/src/libraries/System.Runtime.Extensions/tests/System/StringComparer.cs
index 62edd56f51cb08..aff008f36ada8a 100644
--- a/src/libraries/System.Runtime.Extensions/tests/System/StringComparer.cs
+++ b/src/libraries/System.Runtime.Extensions/tests/System/StringComparer.cs
@@ -96,6 +96,7 @@ public static IEnumerable<object[]> UpperLowerCasing_TestData()
 
         [Theory]
         [MemberData(nameof(UpperLowerCasing_TestData))]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49931", TestPlatforms.Android)]
         public static void CreateWithCulturesTest(string lowerForm, string upperForm, string cultureName)
         {
             CultureInfo ci = CultureInfo.GetCultureInfo(cultureName);
@@ -195,6 +196,7 @@ public static void FromComparisonInvalidTest()
         [ConditionalTheory(typeof(PlatformDetection), nameof(PlatformDetection.IsNotInvariantGlobalization))]
         [MemberData(nameof(CreateFromCultureAndOptionsData))]
         [MemberData(nameof(CreateFromCultureAndOptionsStringSortData))]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49931", TestPlatforms.Android)]
         public static void CreateFromCultureAndOptions(string actualString, string expectedString, string cultureName, CompareOptions options, bool result)
         {
             CultureInfo ci = CultureInfo.GetCultureInfo(cultureName);
@@ -206,6 +208,7 @@ public static void CreateFromCultureAndOptions(string actualString, string expec
 
         [ConditionalTheory(typeof(PlatformDetection), nameof(PlatformDetection.IsNotInvariantGlobalization))]
         [MemberData(nameof(CreateFromCultureAndOptionsData))]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49931", TestPlatforms.Android)]
         public static void CreateFromCultureAndOptionsStringSort(string actualString, string expectedString, string cultureName, CompareOptions options, bool result)
         {
             CultureInfo ci = CultureInfo.GetCultureInfo(cultureName);
diff --git a/src/libraries/System.Runtime.InteropServices/tests/System/Runtime/InteropServices/Marshal/OffsetOfTests.cs b/src/libraries/System.Runtime.InteropServices/tests/System/Runtime/InteropServices/Marshal/OffsetOfTests.cs
index f299734d5a9a1c..dd3ccea3e2dc49 100644
--- a/src/libraries/System.Runtime.InteropServices/tests/System/Runtime/InteropServices/Marshal/OffsetOfTests.cs
+++ b/src/libraries/System.Runtime.InteropServices/tests/System/Runtime/InteropServices/Marshal/OffsetOfTests.cs
@@ -33,6 +33,7 @@ public void OffsetOf_ClassWithSequentialLayout_ReturnsExpected()
         }
 
         [Fact]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49872", TestPlatforms.Android)]
         public void OffsetOf_ExplicitLayout_ReturnsExpected()
         {
             Type t = typeof(ExplicitLayoutTest);
@@ -105,6 +106,7 @@ public void OffsetOf_ValidField_ReturnsExpected()
         }
 
         [Fact]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49872", TestPlatforms.Android)]
         public void OffsetOf_Decimal_ReturnsExpected()
         {
             Type t = typeof(FieldAlignmentTest_Decimal);
diff --git a/src/libraries/System.Security.Cryptography.Algorithms/src/System.Security.Cryptography.Algorithms.csproj b/src/libraries/System.Security.Cryptography.Algorithms/src/System.Security.Cryptography.Algorithms.csproj
index 597e962d93a26c..a2f08a223a4f17 100644
--- a/src/libraries/System.Security.Cryptography.Algorithms/src/System.Security.Cryptography.Algorithms.csproj
+++ b/src/libraries/System.Security.Cryptography.Algorithms/src/System.Security.Cryptography.Algorithms.csproj
@@ -9,9 +9,7 @@
   <Import Project="$(CommonPath)System\Security\Cryptography\Asn1\AsnXml.targets" />
   <Import Project="$(CommonPath)System\Security\Cryptography\Asn1Reader\System.Security.Cryptography.Asn1Reader.Shared.projitems" />
   <PropertyGroup>
-    <!-- Use Android native crypto when ANDROID_OPENSSL_AAR is not defined.
-         TODO: [AndroidCrypto] Remove ANDROID_OPENSSL_AAR check once Android native crypto is complete -->
-    <UseAndroidCrypto Condition="'$(TargetsAndroid)' == 'true' and '$(ANDROID_OPENSSL_AAR)' == ''">true</UseAndroidCrypto>
+    <UseAndroidCrypto Condition="'$(TargetsAndroid)' == 'true'">true</UseAndroidCrypto>
     <UseAppleCrypto Condition="'$(TargetsOSX)' == 'true' or '$(TargetsiOS)' == 'true' or '$(TargetstvOS)' == 'true'">true</UseAppleCrypto>
     <GeneratePlatformNotSupportedAssemblyMessage Condition="'$(TargetsBrowser)' == 'true'">SR.SystemSecurityCryptographyAlgorithms_PlatformNotSupported</GeneratePlatformNotSupportedAssemblyMessage>
     <ApiExclusionListPath Condition="'$(TargetsBrowser)' == 'true'">ExcludeApiList.PNSE.Browser.txt</ApiExclusionListPath>
diff --git a/src/libraries/System.Security.Cryptography.Algorithms/tests/System.Security.Cryptography.Algorithms.Tests.csproj b/src/libraries/System.Security.Cryptography.Algorithms/tests/System.Security.Cryptography.Algorithms.Tests.csproj
index d761bed32cac7e..77ce3aa220dfc4 100644
--- a/src/libraries/System.Security.Cryptography.Algorithms/tests/System.Security.Cryptography.Algorithms.Tests.csproj
+++ b/src/libraries/System.Security.Cryptography.Algorithms/tests/System.Security.Cryptography.Algorithms.Tests.csproj
@@ -1,9 +1,7 @@
 <Project Sdk="Microsoft.NET.Sdk">
   <PropertyGroup>
     <TargetFrameworks>$(NetCoreAppCurrent)-windows;$(NetCoreAppCurrent)-Unix;$(NetCoreAppCurrent)-Android;$(NetCoreAppCurrent)-Browser</TargetFrameworks>
-    <!-- Use Android native crypto when ANDROID_OPENSSL_AAR is not defined.
-         TODO: [AndroidCrypto] Remove ANDROID_OPENSSL_AAR check once Android native crypto is complete -->
-    <UseAndroidCrypto Condition="'$(TargetsAndroid)' == 'true' and '$(ANDROID_OPENSSL_AAR)' == ''">true</UseAndroidCrypto>
+    <UseAndroidCrypto Condition="'$(TargetsAndroid)' == 'true'">true</UseAndroidCrypto>
     <UseAppleCrypto Condition="'$(TargetsOSX)' == 'true' or '$(TargetsiOS)' == 'true' or '$(TargetstvOS)' == 'true'">true</UseAppleCrypto>
   </PropertyGroup>
   <ItemGroup>
diff --git a/src/libraries/System.Security.Cryptography.Encoding/src/System.Security.Cryptography.Encoding.csproj b/src/libraries/System.Security.Cryptography.Encoding/src/System.Security.Cryptography.Encoding.csproj
index 22f3d55350c20a..ea5329594dcfb0 100644
--- a/src/libraries/System.Security.Cryptography.Encoding/src/System.Security.Cryptography.Encoding.csproj
+++ b/src/libraries/System.Security.Cryptography.Encoding/src/System.Security.Cryptography.Encoding.csproj
@@ -8,9 +8,7 @@
     <GeneratePlatformNotSupportedAssemblyMessage Condition="'$(TargetsAnyOS)' == 'true'">SR.SystemSecurityCryptographyEncoding_PlatformNotSupported</GeneratePlatformNotSupportedAssemblyMessage>
   </PropertyGroup>
   <PropertyGroup>
-    <!-- Use Android native crypto when ANDROID_OPENSSL_AAR is not defined.
-         TODO: [AndroidCrypto] Remove ANDROID_OPENSSL_AAR check once Android native crypto is complete -->
-    <UseAndroidCrypto Condition="'$(TargetsAndroid)' == 'true' and '$(ANDROID_OPENSSL_AAR)' == ''">true</UseAndroidCrypto>
+    <UseAndroidCrypto Condition="'$(TargetsAndroid)' == 'true'">true</UseAndroidCrypto>
     <UseAppleCrypto Condition="'$(TargetsOSX)' == 'true' or '$(TargetsiOS)' == 'true' or '$(TargetstvOS)' == 'true'">true</UseAppleCrypto>
   </PropertyGroup>
   <Import Project="$(CommonPath)System\Security\Cryptography\Asn1\AsnXml.targets" Condition="'$(UseAndroidCrypto)' == 'true' or '$(UseAppleCrypto)' == 'true'" />
diff --git a/src/libraries/System.Security.Cryptography.X509Certificates/src/System.Security.Cryptography.X509Certificates.csproj b/src/libraries/System.Security.Cryptography.X509Certificates/src/System.Security.Cryptography.X509Certificates.csproj
index 88e77c662a9427..ba34d878357480 100644
--- a/src/libraries/System.Security.Cryptography.X509Certificates/src/System.Security.Cryptography.X509Certificates.csproj
+++ b/src/libraries/System.Security.Cryptography.X509Certificates/src/System.Security.Cryptography.X509Certificates.csproj
@@ -10,9 +10,7 @@
     <GeneratePlatformNotSupportedAssemblyMessage>SR.SystemSecurityCryptographyX509Certificates_PlatformNotSupported</GeneratePlatformNotSupportedAssemblyMessage>
   </PropertyGroup>
   <PropertyGroup>
-    <!-- Use Android native crypto when ANDROID_OPENSSL_AAR is not defined.
-         TODO: [AndroidCrypto] Remove ANDROID_OPENSSL_AAR check once Android native crypto is complete -->
-    <UseAndroidCrypto Condition="'$(TargetsAndroid)' == 'true' and '$(ANDROID_OPENSSL_AAR)' == ''">true</UseAndroidCrypto>
+    <UseAndroidCrypto Condition="'$(TargetsAndroid)' == 'true'">true</UseAndroidCrypto>
     <UseAppleCrypto Condition="'$(TargetsOSX)' == 'true' or '$(TargetsiOS)' == 'true' or '$(TargetstvOS)' == 'true'">true</UseAppleCrypto>
   </PropertyGroup>
   <Import Project="$(CommonPath)System\Security\Cryptography\Asn1\AsnXml.targets" />
diff --git a/src/libraries/System.Security.Cryptography.X509Certificates/tests/System.Security.Cryptography.X509Certificates.Tests.csproj b/src/libraries/System.Security.Cryptography.X509Certificates/tests/System.Security.Cryptography.X509Certificates.Tests.csproj
index e58fcfee9e437c..53d0dd75a0baa1 100644
--- a/src/libraries/System.Security.Cryptography.X509Certificates/tests/System.Security.Cryptography.X509Certificates.Tests.csproj
+++ b/src/libraries/System.Security.Cryptography.X509Certificates/tests/System.Security.Cryptography.X509Certificates.Tests.csproj
@@ -7,9 +7,7 @@
     <TargetFrameworks>$(NetCoreAppCurrent)-windows;$(NetCoreAppCurrent)-Unix;$(NetCoreAppCurrent)-Android;$(NetCoreAppCurrent)-Browser;$(NetCoreAppCurrent)-OSX;$(NetCoreAppCurrent)-iOS;$(NetCoreAppCurrent)-tvOS</TargetFrameworks>
   </PropertyGroup>
   <PropertyGroup>
-    <!-- Use Android native crypto when ANDROID_OPENSSL_AAR is not defined.
-         TODO: [AndroidCrypto] Remove ANDROID_OPENSSL_AAR check once Android native crypto is complete -->
-    <UseAndroidCrypto Condition="'$(TargetsAndroid)' == 'true' and '$(ANDROID_OPENSSL_AAR)' == ''">true</UseAndroidCrypto>
+    <UseAndroidCrypto Condition="'$(TargetsAndroid)' == 'true'">true</UseAndroidCrypto>
     <UseAppleCrypto Condition="'$(TargetsOSX)' == 'true' or '$(TargetsiOS)' == 'true' or '$(TargetstvOS)' == 'true'">true</UseAppleCrypto>
   </PropertyGroup>
   <Import Project="$(CommonPath)System\Security\Cryptography\Asn1Reader\System.Security.Cryptography.Asn1Reader.Shared.projitems" />
diff --git a/src/libraries/System.Security.Cryptography.Xml/tests/EncryptedXmlTests.cs b/src/libraries/System.Security.Cryptography.Xml/tests/EncryptedXmlTests.cs
index 286c089a237872..281d74a50d2b1a 100644
--- a/src/libraries/System.Security.Cryptography.Xml/tests/EncryptedXmlTests.cs
+++ b/src/libraries/System.Security.Cryptography.Xml/tests/EncryptedXmlTests.cs
@@ -11,6 +11,7 @@ namespace System.Security.Cryptography.Xml.Tests
     public static class EncryptedXmlTests
     {
         [Fact]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49871", TestPlatforms.Android)]
         public static void DecryptWithCertificate_NotInStore()
         {
             const string SecretMessage = "Grilled cheese is tasty";
diff --git a/src/libraries/System.Text.Json/tests/Serialization/NumberHandlingTests.cs b/src/libraries/System.Text.Json/tests/Serialization/NumberHandlingTests.cs
index 83440a15969be7..ed58392341ef61 100644
--- a/src/libraries/System.Text.Json/tests/Serialization/NumberHandlingTests.cs
+++ b/src/libraries/System.Text.Json/tests/Serialization/NumberHandlingTests.cs
@@ -359,6 +359,7 @@ public class Class_With_ListsOfBoxedNonNumbers
         }
 
         [Fact]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49936", TestPlatforms.Android)]
         public static void Number_AsCollectionElement_RoundTrip()
         {
             RunAsCollectionElementTest(JsonNumberTestData.Bytes);
@@ -980,6 +981,7 @@ private static void AssertUnsupportedFormatThrows<T>()
         }
 
         [Fact]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49936", TestPlatforms.Android)]
         public static void EscapingTest()
         {
             // Cause all characters to be escaped.
diff --git a/src/libraries/System.Threading/tests/AutoResetEventTests.cs b/src/libraries/System.Threading/tests/AutoResetEventTests.cs
index 749ea18d935310..4b0818bfe0f5e6 100644
--- a/src/libraries/System.Threading/tests/AutoResetEventTests.cs
+++ b/src/libraries/System.Threading/tests/AutoResetEventTests.cs
@@ -44,6 +44,7 @@ public void WaitHandleWait_Invalid()
         }
 
         [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsThreadingSupported))]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49890", TestPlatforms.Android)]
         public void WaitHandleWaitAll()
         {
             AutoResetEvent[] handles = new AutoResetEvent[10];
@@ -62,6 +63,7 @@ public void WaitHandleWaitAll()
         }
 
         [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsThreadingSupported))]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49890", TestPlatforms.Android)]
         public void WaitHandleWaitAny()
         {
             AutoResetEvent[] handles = new AutoResetEvent[10];
@@ -76,6 +78,7 @@ public void WaitHandleWaitAny()
         }
 
         [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsThreadingSupported))]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49890", TestPlatforms.Android)]
         public void PingPong()
         {
             using (AutoResetEvent are1 = new AutoResetEvent(true), are2 = new AutoResetEvent(false))
diff --git a/src/libraries/System.Threading/tests/ExecutionContextTests.cs b/src/libraries/System.Threading/tests/ExecutionContextTests.cs
index 2054fb3045f69c..d813813bbc5535 100644
--- a/src/libraries/System.Threading/tests/ExecutionContextTests.cs
+++ b/src/libraries/System.Threading/tests/ExecutionContextTests.cs
@@ -62,6 +62,7 @@ public static void DisposeTest()
         }
 
         [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsThreadingSupported))]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49890", TestPlatforms.Android)]
         public static void FlowTest()
         {
             ThreadTestHelpers.RunTestInBackgroundThread(() =>
diff --git a/src/libraries/System.Threading/tests/ManualResetEventTests.cs b/src/libraries/System.Threading/tests/ManualResetEventTests.cs
index 5079cf85053b83..5d170f089c0f0b 100644
--- a/src/libraries/System.Threading/tests/ManualResetEventTests.cs
+++ b/src/libraries/System.Threading/tests/ManualResetEventTests.cs
@@ -37,6 +37,7 @@ public void SetReset()
         }
 
         [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsThreadingSupported))]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49890", TestPlatforms.Android)]
         public void WaitHandleWaitAll()
         {
             ManualResetEvent[] handles = new ManualResetEvent[10];
@@ -55,6 +56,7 @@ public void WaitHandleWaitAll()
         }
 
         [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsThreadingSupported))]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49890", TestPlatforms.Android)]
         public void WaitHandleWaitAny()
         {
             ManualResetEvent[] handles = new ManualResetEvent[10];
@@ -69,6 +71,7 @@ public void WaitHandleWaitAny()
         }
 
         [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsThreadingSupported))]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49890", TestPlatforms.Android)]
         public void PingPong()
         {
             using (ManualResetEvent mre1 = new ManualResetEvent(true), mre2 = new ManualResetEvent(false))
diff --git a/src/libraries/System.Threading/tests/ReaderWriterLockTests.cs b/src/libraries/System.Threading/tests/ReaderWriterLockTests.cs
index 370a5132dc5ecc..d7c08c6711865b 100644
--- a/src/libraries/System.Threading/tests/ReaderWriterLockTests.cs
+++ b/src/libraries/System.Threading/tests/ReaderWriterLockTests.cs
@@ -122,6 +122,7 @@ public static void InvalidLockCookieTest()
         }
 
         [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsThreadingSupported))]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49890", TestPlatforms.Android)]
         public static void BasicLockTest()
         {
             var trwl = new TestReaderWriterLock();
@@ -510,6 +511,7 @@ public static void WaitingReadersTest()
         }
 
         [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsThreadingSupported))]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49890", TestPlatforms.Android)]
         public static void WaitingWritersTest()
         {
             var trwl = new TestReaderWriterLock();
@@ -541,6 +543,7 @@ public static void WaitingWritersTest()
         }
 
         [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsThreadingSupported))]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49890", TestPlatforms.Android)]
         public static void ReadersWaitingOnWaitingWriterTest()
         {
             var trwl = new TestReaderWriterLock();
@@ -591,6 +594,7 @@ public static void ReadersWaitingOnWaitingWriterTest()
         }
 
         [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsThreadingSupported))]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49890", TestPlatforms.Android)]
         public static void ReadersWaitingOnWaitingUpgraderTest()
         {
             var trwl = new TestReaderWriterLock();
@@ -644,6 +648,7 @@ public static void ReadersWaitingOnWaitingUpgraderTest()
         }
 
         [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsThreadingSupported))]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49890", TestPlatforms.Android)]
         public static void WaitingUpgradersTest()
         {
             var trwl = new TestReaderWriterLock();
@@ -689,6 +694,7 @@ public static void WaitingUpgradersTest()
         }
 
         [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsThreadingSupported))]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49890", TestPlatforms.Android)]
         public static void AtomicRecursiveReaderTest()
         {
             var trwl = new TestReaderWriterLock();
@@ -715,6 +721,7 @@ public static void AtomicRecursiveReaderTest()
         }
 
         [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsThreadingSupported))]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49890", TestPlatforms.Android)]
         public static void AtomicDowngradeTest()
         {
             var trwl = new TestReaderWriterLock();
diff --git a/src/libraries/System.Threading/tests/SemaphoreTests.cs b/src/libraries/System.Threading/tests/SemaphoreTests.cs
index b6c762d8c6609f..35d52e599dbfc8 100644
--- a/src/libraries/System.Threading/tests/SemaphoreTests.cs
+++ b/src/libraries/System.Threading/tests/SemaphoreTests.cs
@@ -139,6 +139,7 @@ public void Release()
         }
 
         [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsThreadingSupported))]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/49890", TestPlatforms.Android)]
         public void AnonymousProducerConsumer()
         {
             using (Semaphore s = new Semaphore(0, int.MaxValue))
diff --git a/src/libraries/tests.proj b/src/libraries/tests.proj
index 49a1103f233575..55fdbc13f9f1fb 100644
--- a/src/libraries/tests.proj
+++ b/src/libraries/tests.proj
@@ -20,7 +20,15 @@
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Transactions.Local\tests\System.Transactions.Local.Tests.csproj" />
   </ItemGroup>
 
+  <ItemGroup Condition="'$(TargetOS)' == 'Android'">
+    <!-- Never going to run on Android -->
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Security.Cryptography.OpenSsl\tests\System.Security.Cryptography.OpenSsl.Tests.csproj" />
+  </ItemGroup>
+
   <ItemGroup Condition="'$(TargetOS)' == 'Android' and '$(RunDisabledAndroidTests)' != 'true'">
+    <!-- Test flakiness on x64 https://github.com/dotnet/runtime/issues/49937 -->
+    <ProjectExclusions Condition="'$(TargetArchitecture)' == 'x64'" Include="$(MSBuildThisFileDirectory)System.Threading\tests\System.Threading.Tests.csproj" />
+
     <!-- Tests time out intermittently -->
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)Microsoft.Extensions.Hosting\tests\UnitTests\Microsoft.Extensions.Hosting.Unit.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Threading.Tasks.Parallel\tests\System.Threading.Tasks.Parallel.Tests.csproj" />
@@ -36,28 +44,24 @@
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.IO.FileSystem\tests\System.IO.FileSystem.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Runtime.Numerics\tests\System.Runtime.Numerics.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Runtime.Serialization.Formatters\tests\System.Runtime.Serialization.Formatters.Tests.csproj" />
-    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Security.Cryptography.Algorithms\tests\System.Security.Cryptography.Algorithms.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Threading.Tasks\tests\System.Threading.Tasks.Tests.csproj" />
 
     <!-- Actual test failures -->
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)Microsoft.Extensions.Logging.Console\tests\Microsoft.Extensions.Logging.Console.Tests\Microsoft.Extensions.Logging.Console.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)Microsoft.VisualBasic.Core\tests\Microsoft.VisualBasic.Core.Tests.csproj" />
-    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Collections.Immutable\tests\System.Collections.Immutable.Tests.csproj" />
-    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Collections.NonGeneric\tests\System.Collections.NonGeneric.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Console\tests\System.Console.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Diagnostics.Debug\tests\System.Diagnostics.Debug.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Diagnostics.DiagnosticSource\tests\TestWithConfigSwitches\System.Diagnostics.DiagnosticSource.Switches.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Globalization\tests\System.Globalization.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Globalization.Calendars\tests\System.Globalization.Calendars.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Globalization.Extensions\tests\System.Globalization.Extensions.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.IO.Compression\tests\System.IO.Compression.Tests.csproj" />
-    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.IO.IsolatedStorage\tests\System.IO.IsolatedStorage.Tests.csproj" />
-    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.IO.Pipes\tests\System.IO.Pipes.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Net.NetworkInformation\tests\FunctionalTests\System.Net.NetworkInformation.Functional.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Net.Ping\tests\FunctionalTests\System.Net.Ping.Functional.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Net.Primitives\tests\FunctionalTests\System.Net.Primitives.Functional.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Net.Requests\tests\System.Net.Requests.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Net.Security\tests\FunctionalTests\System.Net.Security.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Net.Sockets\tests\FunctionalTests\System.Net.Sockets.Tests.csproj" />
-    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Runtime.Extensions\tests\System.Runtime.Extensions.Tests.csproj" />
-    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Runtime.InteropServices.RuntimeInformation\tests\System.Runtime.InteropServices.RuntimeInformation.Tests.csproj" />
-    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Runtime.Loader\tests\DefaultContext\System.Runtime.Loader.DefaultContext.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Runtime\tests\System.Runtime.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Security.Cryptography.X509Certificates\tests\System.Security.Cryptography.X509Certificates.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Text.Encoding\tests\System.Text.Encoding.Tests.csproj" />
diff --git a/src/mono/sample/Android/AndroidSampleApp.csproj b/src/mono/sample/Android/AndroidSampleApp.csproj
index 0853fd97915bb4..8dbf637c281200 100644
--- a/src/mono/sample/Android/AndroidSampleApp.csproj
+++ b/src/mono/sample/Android/AndroidSampleApp.csproj
@@ -55,14 +55,6 @@
       <AndroidAbi Condition="'$(TargetArchitecture)' == 'x86'">x86</AndroidAbi>
     </PropertyGroup>
 
-    <!-- TODO: delete once we switch to Android Crypto -->
-    <Copy Condition="'$(ANDROID_OPENSSL_AAR)' != ''"
-          SourceFiles="$(ANDROID_OPENSSL_AAR)\prefab\modules\crypto\libs\android.$(AndroidAbi)\libcrypto.so"
-          DestinationFolder="$(PublishDir)" SkipUnchangedFiles="true"/>
-    <Copy Condition="'$(ANDROID_OPENSSL_AAR)' != ''"
-          SourceFiles="$(ANDROID_OPENSSL_AAR)\prefab\modules\ssl\libs\android.$(AndroidAbi)\libssl.so"
-          DestinationFolder="$(PublishDir)" SkipUnchangedFiles="true"/>
-
     <Message Importance="High" Text="Path: $(PublishDir)" />
     <Message Importance="High" Text="SourceDir: $(OutputPath)" />
 
diff --git a/src/tests/run.proj b/src/tests/run.proj
index 88123dfe941520..f5a67ace8c54a5 100644
--- a/src/tests/run.proj
+++ b/src/tests/run.proj
@@ -473,15 +473,6 @@ namespace $([System.String]::Copy($(Category)).Replace(".","_").Replace("\","").
         SourceFiles="@(RuntimePackLibs)"
         DestinationFolder="$(BuildDir)" />
 
-    <!-- TEMP: consume OpenSSL binaries from external sources via env. variables.-->
-    <Copy Condition="'$(ANDROID_OPENSSL_AAR)' != ''"
-          SourceFiles="$(ANDROID_OPENSSL_AAR)\prefab\modules\crypto\libs\android.$(AndroidAbi)\libcrypto.so"
-          DestinationFolder="$(BuildDir)" SkipUnchangedFiles="true"/>
-
-    <Copy Condition="'$(ANDROID_OPENSSL_AAR)' != ''"
-          SourceFiles="$(ANDROID_OPENSSL_AAR)\prefab\modules\ssl\libs\android.$(AndroidAbi)\libssl.so"
-          DestinationFolder="$(BuildDir)" SkipUnchangedFiles="true"/>
-
     <AndroidAppBuilderTask
         RuntimeIdentifier="$(RuntimeIdentifier)"
         ProjectName="$(Category)"
