diff --git a/package-lock.json b/package-lock.json
index 8fe8a0accd0a..a58d7c308826 100644
--- a/package-lock.json
+++ b/package-lock.json
@@ -77,7 +77,7 @@
         "react-native-key-command": "^1.0.1",
         "react-native-localize": "^2.2.6",
         "react-native-modal": "^13.0.0",
-        "react-native-onyx": "1.0.43",
+        "react-native-onyx": "1.0.50",
         "react-native-pdf": "^6.6.2",
         "react-native-performance": "^4.0.0",
         "react-native-permissions": "^3.0.1",
@@ -36787,9 +36787,9 @@
       }
     },
     "node_modules/react-native-onyx": {
-      "version": "1.0.43",
-      "resolved": "https://registry.npmjs.org/react-native-onyx/-/react-native-onyx-1.0.43.tgz",
-      "integrity": "sha512-NwS1SxZJWhk/7FUAAE9HrnupQR1yrSAheuhggdeA3+oFLn9X6UJM7n7w9DodFqCQbUIUy9biKtYk29sChfk9hQ==",
+      "version": "1.0.50",
+      "resolved": "https://registry.npmjs.org/react-native-onyx/-/react-native-onyx-1.0.50.tgz",
+      "integrity": "sha512-tBqJRUBb2M/giIgqf2V0kw1jMr2iAW64CpgtWJbETv1ihOitP6+YAJpqoPIB0SGSFByfgTYY4k/KSVZBgcynMg==",
       "dependencies": {
         "ascii-table": "0.0.9",
         "fast-equals": "^4.0.3",
@@ -36801,7 +36801,6 @@
         "npm": "8.11.0"
       },
       "peerDependencies": {
-        "expensify-common": ">=1",
         "localforage": "^1.10.0",
         "localforage-removeitems": "^1.4.0",
         "react": ">=18.1.0",
@@ -68550,9 +68549,9 @@
       }
     },
     "react-native-onyx": {
-      "version": "1.0.43",
-      "resolved": "https://registry.npmjs.org/react-native-onyx/-/react-native-onyx-1.0.43.tgz",
-      "integrity": "sha512-NwS1SxZJWhk/7FUAAE9HrnupQR1yrSAheuhggdeA3+oFLn9X6UJM7n7w9DodFqCQbUIUy9biKtYk29sChfk9hQ==",
+      "version": "1.0.50",
+      "resolved": "https://registry.npmjs.org/react-native-onyx/-/react-native-onyx-1.0.50.tgz",
+      "integrity": "sha512-tBqJRUBb2M/giIgqf2V0kw1jMr2iAW64CpgtWJbETv1ihOitP6+YAJpqoPIB0SGSFByfgTYY4k/KSVZBgcynMg==",
       "requires": {
         "ascii-table": "0.0.9",
         "fast-equals": "^4.0.3",
diff --git a/package.json b/package.json
index 92086a9f2173..77495586e16e 100644
--- a/package.json
+++ b/package.json
@@ -115,7 +115,7 @@
     "react-native-key-command": "^1.0.1",
     "react-native-localize": "^2.2.6",
     "react-native-modal": "^13.0.0",
-    "react-native-onyx": "1.0.43",
+    "react-native-onyx": "1.0.50",
     "react-native-pdf": "^6.6.2",
     "react-native-performance": "^4.0.0",
     "react-native-permissions": "^3.0.1",
diff --git a/src/ONYXKEYS.js b/src/ONYXKEYS.js
index 823ad7028a94..c3c76ce4e5d3 100755
--- a/src/ONYXKEYS.js
+++ b/src/ONYXKEYS.js
@@ -230,4 +230,7 @@ export default {
 
     // Report ID of the last report the user viewed as anonymous user
     LAST_OPENED_PUBLIC_ROOM_ID: 'lastOpenedPublicRoomID',
+
+    // Experimental memory only Onyx mode flag
+    IS_USING_MEMORY_ONLY_KEYS: 'isUsingMemoryOnlyKeys',
 };
diff --git a/src/libs/Navigation/AppNavigator/AuthScreens.js b/src/libs/Navigation/AppNavigator/AuthScreens.js
index c2fe7d3475e0..6c5ca155f6b7 100644
--- a/src/libs/Navigation/AppNavigator/AuthScreens.js
+++ b/src/libs/Navigation/AppNavigator/AuthScreens.js
@@ -91,10 +91,14 @@ const propTypes = {
     /** The report ID of the last opened public room as anonymous user */
     lastOpenedPublicRoomID: PropTypes.string,
 
+    /** Opt-in experimental mode that prevents certain Onyx keys from persisting to disk */
+    isUsingMemoryOnlyKeys: PropTypes.bool,
+
     ...windowDimensionsPropTypes,
 };
 
 const defaultProps = {
+    isUsingMemoryOnlyKeys: false,
     session: {
         email: null,
     },
@@ -122,7 +126,10 @@ class AuthScreens extends React.Component {
 
         // If we are on this screen then we are "logged in", but the user might not have "just logged in". They could be reopening the app
         // or returning from background. If so, we'll assume they have some app data already and we can call reconnectApp() instead of openApp().
-        if (SessionUtils.didUserLogInDuringSession()) {
+        // Note: If a Guide has enabled the memory only key mode then we do want to run OpenApp as their app will not be rehydrated with
+        // the correct state on refresh. They are explicitly opting out of storing data they would need (i.e. reports_) to take advantage of
+        // the optimizations performed during ReconnectApp.
+        if (this.props.isUsingMemoryOnlyKeys || SessionUtils.didUserLogInDuringSession()) {
             App.openApp();
         } else {
             App.reconnectApp();
@@ -308,5 +315,8 @@ export default compose(
         lastOpenedPublicRoomID: {
             key: ONYXKEYS.LAST_OPENED_PUBLIC_ROOM_ID,
         },
+        isUsingMemoryOnlyKeys: {
+            key: ONYXKEYS.IS_USING_MEMORY_ONLY_KEYS,
+        },
     }),
 )(AuthScreens);
diff --git a/src/setup/index.js b/src/setup/index.js
index 92a84d45a571..dee506302e81 100644
--- a/src/setup/index.js
+++ b/src/setup/index.js
@@ -42,6 +42,19 @@ export default function () {
         },
     });
 
+    // When enabled we will skip persisting to disk any server-side downloaded objects (e.g. workspaces, chats, etc) that can hog up a user's resources.
+    window.enableMemoryOnlyKeys = () => {
+        // eslint-disable-next-line rulesdir/prefer-actions-set-data
+        Onyx.set(ONYXKEYS.IS_USING_MEMORY_ONLY_KEYS, true);
+        Onyx.setMemoryOnlyKeys([ONYXKEYS.COLLECTION.REPORT, ONYXKEYS.COLLECTION.POLICY, ONYXKEYS.PERSONAL_DETAILS_LIST]);
+    };
+
+    window.disableMemoryOnlyKeys = () => {
+        // eslint-disable-next-line rulesdir/prefer-actions-set-data
+        Onyx.set(ONYXKEYS.IS_USING_MEMORY_ONLY_KEYS, false);
+        Onyx.setMemoryOnlyKeys([]);
+    };
+
     Device.setDeviceID();
 
     // Force app layout to work left to right because our design does not currently support devices using this mode